The heritability of the immune system is ~40%. Recent genome wide association studies (GWAS) have identified common genetic variants associated with multiple immune phenotypes such as cell proportions and protein expression. Integrating host genetic data with humoral response to viral infections may aid our understanding of the inter-individual differences in the immune response and disease outcome. A total of 612 participants from USA, 262 females and 343 males, with mean age 34.2 years (18 – 70 years) were enrolled in this study and had serum samples tested for the humoral response to viral epitopes using phage immunoprecipitation sequencing (PhIP-seq) technology.